TCT-214 Pharmacodynamic Effects of Ticagrelor and Eptifibatide Bolus-Only vs. Ticagrelor and Eptifibatide Bolus plus 2 h Infusion in Patients with Acute Coronary Syndrome
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چکیده
منابع مشابه
Ticagrelor and Eptifibatide Bolus Versus Ticagrelor and Eptifibatide Bolus With 2‐Hour Infusion in High‐Risk Acute Coronary Syndromes Patients Undergoing Early Percutaneous Coronary Intervention
BACKGROUND In patients with non-ST-segment elevation acute coronary syndromes, inhibition of platelet aggregation (IPA) with a potent P2Y12 inhibitor, ticagrelor, was inferior to tirofiban infusion at 2 hours, indicating that glycoprotein IIb/IIIa inhibitors are still needed. Ticagrelor and eptifibatide bolus only may maximally inhibit platelet aggregation and decrease bleeding, but IPA with ti...
متن کاملDyspnoea management in acute coronary syndrome patients treated with ticagrelor
The occurrence of dyspnoea in acute coronary syndrome (ACS) patients has always been considered a challenging diagnostic and therapeutic clinical scenario. P2Y12 platelet receptor inhibitors (i.e., clopidogrel, prasugrel and ticagrelor) are currently the cornerstone of treatment of ACS patients. Thus, in the last few years, the potential association between ACS and dyspnoea has also become more...
متن کاملPharmacodynamic effects during the transition between cangrelor and ticagrelor.
OBJECTIVES This study sought to determine pharmacodynamic effects during transition from intravenous cangrelor to oral ticagrelor and from oral ticagrelor to intravenous cangrelor. BACKGROUND Cangrelor is an intravenous antagonist of P2Y12 and its use will require transition to and from oral agents. METHODS Patients (n = 12) with stable coronary artery disease who were taking aspirin 81 mg ...
متن کاملPharmacodynamics and pharmacokinetics of higher-dose, double-bolus eptifibatide in percutaneous coronary intervention.
BACKGROUND Pharmacodynamics of eptifibatide, a cyclic heptapeptide antagonist of platelet glycoprotein IIb/IIIa, are substantially altered by anticoagulants that chelate calcium, resulting in overestimation ex vivo of the in vivo effects of this agent. We conducted a dose-ranging study to characterize the pharmacodynamics and pharmacokinetics of eptifibatide under physiological conditions. ME...
متن کاملComparison between bolus intracoronary versus bolus intravenous injection regimens of eptifibatide during primary PCI in patients with anterior STEMI.
Prospective, controlled, randomized study enrolled 100 patients with acute anterior STEMI eligible for primary PCI equally divided into 2 groups (group A received bolus intracoronary eptifibatide and group B received it intravenous) followed by 12h continuous IV infusion. Predictors of myocardial salvage in the form of TIMI flow grade III, myocardial blush grade 3, ST segment resolution and lef...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2015
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2015.08.229